Every year, farmers in sub-Saharan Africa suffer from unacceptable levels of crop loss as a result of plant health problems, threatening their food security, income and livelihoods. This working paper shares lessons from Plantwise, an initiative to improve smallholder farmers’ access to plant health services in Uganda so that they can improve their yields, increase their incomes and improve their food security and livelihoods. The working paper presents lessons from almost ten years of experiences in implementing plant clinics in Uganda.