The inadequate linkage of knowledge generation in agricultural research organizations with policy-making and economic activity is an important barrier to sustainable development and poverty reduction. The emerging fields of sustainability science and innovation systems studies highlight the importance of “boundary management” and “innovation brokering” in linking knowledge production, policy-making, and economic activities. This paper analyzes how the Papa Andina Partnership Program, based at the International Potato Center, functions as an innovation broker in the Andean potato sector.