Drawn from numerous sources, including papers in this journal, this concluding paper synthesizes evidence on the relationship between agricultural research for development and poverty reduction, with particular emphasis on agri-food systems perspectives in shaping programs aimed at rural prosperity. Following the introduction in section 1, we revisit the ex ante set of 18 pathways in section 2 (which were laid out in our introductory paper for this SI), posing some critical questions: Can a manageable set of impact pathways be identified? How are they inter-related?