Climate-smart agriculture (CSA) is an approach to help agricultural systems worldwide, concurrently addressing three challenge areas: increased adaptation to climate change, mitigation of climate change, and ensuring global food security – through innovative policies, practices, and financing. It involves a set of objectives and multiple transformative transitions for which there are newly identified knowledge gaps. We address these questions raised by CSA within three areas: conceptualization, implementation, and implications for policy and decision-makers.